EQUIVIT B - QUIET

A supplemental source of Thiamine (Vitamin B1) to help calm nervous, hot or highly strung horses where bahaviour is related to thiamine deficiency.

Many horses are difficult to handle and do not fulfill their full potential as a resulf of spookiness or nervousness.

A deficiency of thiamine has been shown in several species to lead to nervous behaviour. B-QUIET provides concentrated levels of thiamine to treat the symptoms of thiamine deficiency, including hyper-irritability and nervousness in horses. Thiamine plays an important role in carbohydrate metabolism and nerve transmission.Thiamine deficiency can sometimes be caused by grazing on bracken fern.
B-QUIET is also useful for horses on high grain intakes and in heavy training, to aid energy utilisation and promote appetite. In these horses, production of thiamine by intestinal bacteria may be reduced by stress and hind gut acidosis.

USES:

. Excitable and highly strung horses
. Horses that are poor travellers and nervous away from home
. Horses that are nervous, and prone to tie up
. Mares who become irritable when in season
. Horses "heated up" by grain
. Instead of injectible Vitamin B1

ACTIVE CONSTITUENTS:

Thiamine (Vitamin B1) 1,000mg - 33,333mg

AVAILABLE PACK SIZES: 600g (trial pack), 1kg and 4kg

DIRECTIONS FOR USE:

For nervous horses, and other horses showing signs of thiamine deficiency, use 30g per day mixed in the feed for as long as signs persist. Feed 30g per day mixed in feed to horses on high grain intakes in heavy training. Double doses may be given for 2 days prior to a show competition or racing to enhance the calming effect.

1 heaped scoop = 30g

Other feeding managements practices to reduce nervous behaviour should also be used. Match energy intake with body condition and workload. This includes the use of high fat supplements such as KER EQUI-JEWEL or "cool" prepared feeds. If further supplementation with high levels of other B vitamins is needed, EQUIVIT HEMABUILD can be used.

EQUI - JEWEL

High-Fat Stabilised Rice Bran with Calcium, Vitamin E and Selenium

Alternative sources of energy, such as rice bran, are now more popular than ever.

Equi-Jewel, a high-fat stabilised rice bran supplement, increases the energy density of a ration, thereby decreasing the amount of grain necessary to fulfill energy requirements of horses during growth, lactation or athletic performance. Addition of Equi-Jewel to a ration can reduce the risk of founder, colic, diarrhoea and exertional myopathies often associated with excessive grain and minimal forage intake.

Equi-Jewel contains a balanced calcium to phosphorus ration. In its natural state, rice bran is richer in phosphorus than in calcium.

Excessive phosphorus in the diet inhibits calcium absorption, which may compromise skeletal integrity or induce developmental orthopaedic disease. Inclusion of calsium carbonate ensures a balanced calcium to phosphorus ratio in the diet of a horse, and can be used as a calcium supplement.

To achieve superior coat condition, Equi-Jewel can be suppplemented to horses of all ages. Equi-Jewel is a highly digestible and higly palatable source of unsaturated fat for horses. Fats are composed of glycerol and essential fatty acids, elements linked to elastic skin and glossy hair coats.

BENEFITS:

. Provides fatty acids essential for healthy skin and hair

. Improves and maintains condition on poor doers and picky eaters

. Enhances palatability and convenience compared to oil

. Delivers low starch and low glycemic index for horses prone to tying up and

behavioural problems

. Stabilised to protect nutritional value and retain freshness

. Adds calories to a ration without excessive grain intake

. Supplies a highly palatable and digestible form of fat

. Contains balanced ratio of calcium to phosphorus

ACTIVE CONSTITUENTS:

Crude Protein (min) 13%

Crude Fat (min) 17.5%

Crude Fiber (max) 13%

Calcium to Phosphorus Ratio 1 : 5 : 1

Vitamin E 650IU/kg

Selenium 1mg/kg

DE 15MJ/

HYGAIN MICRBARLEY

Micronizing is a "Short Time, High Temperature" patented process using the grains moisture and infrared heat to achieve conditions essential for the optimal cooking of starch and starch gelatinisation. During processing the grain becomes soft and pliable, causing the reconfiguration of the starch structure (gelatinisation). Immediate flaking fully gelatinises the starches so as to significantly enhance the digestibility and nutritional value of the feed.

HYGAIN® MICRBARLEY® is readily converted and absorbed as glucose in the small intestine, providing energy more efficiently than starch fermented in the large intestine.

The small intestine is the epicentre of nutrient digestion in the horse. Vitamins, minerals, fats, protein and starch are readily absorbed in the small intestine. Research shows that feed digested in the small intestine significantly increases the rate of glucose (energy) absorption. The starch in HYGAIN® MICRBARLEY® is over 95% digested in the horse's small intestine where as the starch in whole or steam flaked barley is only 20-30% digested. The remaining starch is then fermented in the large intestine,this in turn increases the burden on the large intestine producing elevated levels of lactic acid, gas and heat. Using HYGAIN® MICRBARLEY® transfers the site of digestion back to the small intestine.

ANALYSIS AS FED
Min Crude Protein - 11%

Max Crude Fibre - 9%

Min Crude Fat - 2%

FEEDING GUIDE. Introduce MICRBARLEY® to your horse's diet gradually over a 7 -14 day period.

. Feed horses little and often. No more than 2kg of MICRBARLEY® should be fed at any one time.
. Avoid over feeding as this may impact on the digestive system.
. Feed by weight and not by volume.
. Ensure horses have access to clean drinking water at all times.
. Ensure horses have access to quality roughage.
.During summer months horses may require supplementation of an electrolyte such as

HYGAIN® REGAIN®.

. 1kg of whole or steamed flaked barley can be replaced with approximately 750grams of HYGAIN® MICRBARLEY®.

. HYGAIN® MICRBARLEY® should be fed with roughage and can be mixed with other grains to meet nutrient requirements.

HYGAIN TRACKTORQUE

A high energy balanced feed developed for mature performance horses in full training. TRACKTORQUE'S scientific formula provides a nutritionally complete diet for a professional feeding program.

TRACKTORQUE contains a blend of premium quality grains and essential vitamins and minerals. Scientifically formulated to produce an extremely palatable feed which meets the nutritional requirements of mature horses involved in strenuous exercise.

In the quest for success, todays performance horses are pushed to the limit and have to endure periods of intense work and physical stress. Afundamental part of any successful training program is a nutritionally balanced diet.

ANALYSIS AS FED

Digestible Energy 13.3 MJ/kg

Min Crude Protein 12%

Min Crude fat 6.5%

Max Crude Fibre 9%

Max Added Salt 1.5%

Min Calcium 0.65%

Min Phosphorous 0.5%

Vitamin E 245mg/kg

INGREDIENT COMPOSITION

TRACKTORQUE is a scientifically formulated blend of the following quality ingredients: Cooked and Steam Flaked Oats, Barley, Maize, Sunflower Seeds, Horse Beans, Lupins, Blended Vegetable Oils (including omega essential fatty acids), Calcium Chloride, Vitamin E, Salt, Molasses, Yea Sacc1026 Live Yeast Culture, HYGAIN Selenium Yeast and HYGAIN Vitamin and Mineral Premix.

WHAT IS YEA SACC1026?

Yea Sacc 1026 is a live yeast culture composed of yeast cells from the strain Saccharomyces cerevisiae 1026 and the media on which it is grown.

Yea Sacc 1026 stimulates the growth and activity of specific beneficial bacteria's to aid in hindgut fermentation, mineral absorption and feed utilisation.

BIO SELENIUM YEAST

Selenium acts as an anti oxidant to prevent fatty acid oxidisation which can cause tissue damage. HYGAIN Bio Selenium Yeast is an organic form of selenium which has been shown to be more readily digested and retained than selenium in inorganic form.

BIO CHROMIUM YEAST

TRACKTORQUE is available with HYGAIN Bio Chromium Yeast.The addition of chromium to performance horse diets has been shown to reduce the build up of lactic acid at the end of strenuous exercise or the closing stages of a race, and to increase the horse's ability to store glucose.

ACTIVE CONSTITUENTS:

Calcium 6.5g, Vitamin A 12429 IU

Phosphorous 5g, Vitamin D3 1050IU

Magnesium 2.5g, Vitamin E 165 mg

Sodium 5.7g, Vitamin B1 11mg

Potassium 8g, Vitamin B2 12mg

Chloride 10g, Niacin 54mg

Iron 214mg, D-Cal Pant 20mg

Zinc 125mg, Vitamin B6 6mg

Manganese 100mg, Vitamin B12 35ug

Copper 45mg, Folic Acid 3.4mg

Iodine 0.5mg, Biotin 280ug

Cobalt 0.3mg, Choline 300mg

Selenium 0.5mg, Vitamin K3 5.5mg

FEEDING GUIDE

Introduce TRACKTORQUE to your horse's diet gradually. Feeding amount is dependant on the work load, size and appetite of your horse.

As TRACKTORQUE is a highly palatable, digestible energy source, care should be taken to match feed intake to workload. Reduce TRACKTORQUE intake if horses gain weight, training regime is interrupted and on rest days.

Horses in full work will require on average per day between 5 - 7kg of TRACKTORQUE and 3 - 5kg of quality roughage such as chaff or hay for fibre. The use of additional supplements and grains is not required.

During periods of heavy sweat loss additional supplementation with an electrolyte such as HYGAIN REGAIN is recommended.

TILDREN INJECTION

TILDREN INJECTION

TREATMENT FOR LAMENESS ASSOCIATED WITH BONE AND CARTILAGE CHANGES IN HORSES 骨和软骨的变化，那些慢性疾病病和骨关节的观察，可治疗跛行。 也可治疗舟状骨病和飞节内肿引起骨和软骨改变而出现的跛行。

COMPOSITION TILUDRONIC ACID 50mg/vial.

ACTIONS Tiludronic acid belongs to the bisphosphonate therapeutic class, a class of product with activity on bone metabolism. The main pharmacological property ofTILDREN Injection is to reduce bone resorption by inhibiting the activity of osteoclast. TILDREN Injection acts as a regulator of bone remodelling in all situations involving excessive bone resorption. This regulator effect is not associated with a negative effect of bone formation or bone mineralisation at the recommended therapeutic dosage. Areas of reduced bone density are a pathological change common to most cases of Navicular Disease and Bone spavin and are due to inappropriate resoption of bone (osteolysis). In double-blind, placebo-controlled clinical trials for both conditions, TILDREN treatment induced a clear improvement as demonstrated by long-term reduction in lameness and progressive resumption of sporting activity. In another double-blind, placebo-controlled clinical trial into the treatment of back pain associated with bony lesions of the vertebral column, TILDREN Equine Injection treatment induced a clear improvement in back flexibility, however further research is required to add this indication as a registered claim. Other studies have shown that TILDREN treatment can prevent the bone loss, which usually occurs during inactivity in horses, as shown by measurements of bone density in spelling horses. TILDREN Injection has also demostrated anti-arthritic properties in a model of poly-arthristis in rats. In vitro date identified inhibiting effects on the secretion of enzymes which degrade cartilage matrix. INDICATIONS HORSES: Treatment of lameness associated with bone and cartilage changes such as those observed in Navicular Disease and Bone Spavin.

DOSAGE AND ADMINISTRATION DOSAGE: 0.1mg Tiludronic acid per kg bodyweight once daily for 10 days by slow intravenous injection. i.e. 10mL (1 vial) of reconstituted solution per 500kgbodyweight per day for 10 days. PRESENTATION CARTON CONTAINS: 10 vials of 50mg freeze-dried powder (Tildren) and 10 vails of 10mL solvent (Water for injection). Each carton provides a 10-day treatment course for a 500kg horse. STORAGE Store below 25 celcius (air conditioning) in outer carter.

EFFECT OF TILUDRONATE ON BONE RESOPTION

(1) Binding of Tiludronate via a covalent bond to the mineral phrase of the bone (the hydroxyapatite). This binding occurs preferentially at the remodelling sites. (2) Acidification of th emedium resultingh from the initiation of the resoption process - this breaks the Tilundronate-hydroxyapatite bond. In this way Tildronate is released into the resorption cavity. (3) Penetration of Tiludronate into the osteoclast. (4) . Inhibition of the proton pump... . Disruption of the cytoskeleton leading to the loss of the ruffled border. . Formation of a cytotoxic ATP analogue, which causes the death of the osteoclast.

AMINO ACID-AMP + PYROPHOSPHATE ~~~ ATP + AMINO ACIDS.

Tiludronate replaces the pyrophosphate, hence; AMINO ACID-AMP + TILUDRONATE ~~~ ATP ANALOGUE + AMINO ACID. ACTION OF THE OSTEOBLAST Osteoblast particularly produce interleukin-6 which activates the osteoclasts and thus initates resorption. Tiludronate inhibits the osteoblastic synthesis of interleukin-6.

EFFECT OF TILUDRONATE ON CALCIUM

. Work carried out by Barbier shows that th eintestinal absorption of calcium is increased in a 'DOSE DEPENDENT' manner by Tiludronate, without increasing the excretion of calcium via the urine. . Moreover, Tildronate facilitates the binding of blood calcium to bone, by increasing the size of existing hydroxyapatite crystals or of crystals being formed. . Tiludronate limits the release of bone calcium by inhibiting resorption. THESE RESULTS SHOW THAT TILUDRONATE ENHANCES CALCIUM ABSORPTION AND INCREASES BONE DENSITY. CONCLUSION TILUDRONATE IS A REGULATOR OF BONE REMODELLING: . it reduces bone resorption . it does not have a negative effect on bone formation . it has positive effects on mineralisation and increases bone density. As a consequence of its various pharmacological properties, Tiludronate is very beneficial in the treatment of lameness where bone pathology is involved, in particular, where radiographs show that osteolysis and sclerosis are features of the pathology.

EFFECT ON CARTILAGE In vitro studies have shown that Tiludronate inhibits the secretion, mediated by interleukin-1, of enzymes that degrade the cartilaginous matrix. These enzymes (collagenase and proteoglycan-degrading enzyme) are produced by chondrocytes and the synovial cells. This property of Tiludronate may be beneficial in treating degenerative osteo-articular pathologies.

STUDY OF THE BONE DISTRIBUTION IN HORSES OF TILUDRONATE AS A FUNCTION OF TIME. PROTOCOL . 8 horses (4 males, 4 females). . 0.1 mg/kg/day (as C tiludronate) for 10 consecutive days via the IV route. . Study duration: 6 months. MEASUREMENT OF THE TILUDRONATE CONCENTRATION: DO + 10 DAYS, DO + 3 MONTHS, DO + 6 MONTHS IN THE FEMUR, THE THIRD TARSAL BONE, THE THIRD METACARPAL BONE AND THE NAVICULAR BONE.

RESULTS . The same distribution pattern was observed for males and females, however, the dose bound in the bone was lower for the females. . The bone concentration varied as a function of the bone studied. . The concentration in the bone diminished very slowly between 0 and 3 months; the reduction was more marked after 6 months.

PERCENTAGE OF HORSES WITHDRAWN FROM THE TRIAL AFTER 1 OR 2 MONTHS DUE TO AN INSUFFICIENT RESPONSE TO THE TREATMENT. A FAILURE RATE The investigators could withdraw a horse from the study, if the response to treatment was considered to be insufficient at the 1-month or 2-month examination. - 55% OF THE HORSES IN THE PLACEBO GROUP WERE WITHDRAWN FROM THE STUDY. - NO HORSE IN THE TILDREN GROUP WAS WITH DRAWN FROM THE STUDY.

EVALUATION OF THE DEGREE OF LAMENESS In the placebo group: in the first 2 months there was a reduction in the number of horses presenting with moderate to extreme lameness. After 2 months there was a relapse and at 6 months, 90% of the horses in this group were lame.

IN THE TILDREN GROUP: . There was a progressive and long lasting improvement. After 6 months, 60% of the horses were no longer lame or showed only mild signs, demonstrating the mid-to long-term effect of Tildren.

LEVEL OF ACTIVITY The horse's level of activity is an essential criteria in evaluating the benefit of a treatment. For the treatment to be truly satisfactory, it is important that the horse can resume its sporting activity. The level of activity is evaluated as a function of the type of activity normally carried out by the horse on a scale of 0 (very little activity). ACTIVITY WAS CONSIDERED TO HAVE BEEN RESUMED IF THE SCORE WAS 6 OR 7. . In the Tildren group, a progressive and gradual recovery was noted in the horses's activity. . In the placebo group, the number of horses recovering normal activity levels fluctuated from one consultation to another. At 6 months, none of the horses had a normal level of activity. . After 6 months: more that 67% of the horses had recovered a normal level of activity. . There was a significant difference between the Tildren group and the placebo group: p=0.01

PERCENTAGE OF HORSES WITHDRAWN FROM THE TRIAL AFTER 1 OR 2 MONTHS DUE TO AN INSUFFICIENT RESPONSE TO THE TREATMENT. A FAILURE RATE The investigators could withdraw a horse from the study, if the response to treatment was considered to be insufficient at the 1-month or 2-month examinations. The failure rate corresponds to the percentage of horses withdrawn from the study because of a response deemed to be insufficient. The rate was measured in each group. As can be seen in the graph, by the 2-month examination the two groups were very significantly different: - 38 of the horses in the placebo group were withdrawn from the study. - No horses in the TILDREN group were withdrawn from the study.

HYGAIN GRAIN PRIX

PREMIUM HORSE MIX

Protect your investment with the ultimate in quality and performace.

Correct feeding of your horse is essential to its health and performance. Therefore it is important that your selection of horse feed contains the correct levels of energy, protein, vitamins and minerals essential to form a balanced dite.

GRAND PRIX Premium horse mix is specifically formulated to maximise the condition and performance of competition horse in all disciplines.

GRAND PRIX Premium horse mix is a highly palatable blend of quality MICRONIZED grains, chaff, vitamins and minerals, coated with molasses, ensuring a balanced nutritional diet for any feeding program.

ANALYSIS AS FED

Min Crude Protein 10%

Min Crude Fat 5%

Max Crude Fibre 11%

Max Added Salt 1.25%

Min Calcium 1%

Min Phosphorous 0.6%

INGREDIENT COMPOSITON

GRAND PRIX Premium horse mix is formulated from a blend of the following quality ingredients: Cooked and Flaked Oats, MICRBARLEY, MICRMAIZE, MICRLUPINS, Sunflower Seeds, Lucerne and Oaten Chaff, Molasses, Salt, Calcium Carbonated, Di-Calcium Phosphate, HYGAIN Chromium Yeastand HYGAIN Vitamin and Mineral Premix.

MICRONIZING

Micronization is a patented process by which the grain's moisture and infrared heat is used to reconfigure the grain's structural matrix. This leads to increased feed efficiency, with greater than 90% of the grain's starch being digested in the small intestine. With such an increase in digestion in the small intestine, and hence the reduced burden on the large intestine, this leads to fewer incidences of acidosis, colic, laminitis, fatigue and nervousness.

BIO CHROMIUM YEAST

The addition of organic chromium to performance horse diets has been shown to reduce the build up of lactic acid at the end of strenuous exercise or the closing stages of a race, and to increase the horse's ability to store glucose.

ACTIVE CONSTITUENTS

Calcium 10.7g, Vitamin A 10900IU

Phosphorous 6.3g, Vitamin D3 780IU

Magnesium 2.0g, Vitamin E 250 IU

Sodium 5.7g, Vitamin B1 9mg

Potassium 7g, Vitamin B2 10mg

Chloride 9.3g, Niacin 56.5mg

Iron 256mg, D-Cal Pant 20mg

Zinc 103mg, Vitamin B6 5.2mg

Manganese 89mg, Vitamin B12 25ug

Copper 34mg, Folic Acid 2.2mg

Iodine 0.35mg, Biotin 294ug

Cobait 0.17mg, Vitamin K3 4mg

Selenium 0.5mg, Chromium 0.7mg

FEEDING GUIDE

It is important to remember when feeding, that each horse is an individual and som their nutritional requirements may differ. The following cable is a basic guide to daily feed intake levels required by different classes of horses. Feed intake requirements are dependent on workload, size, weight and age of your horse.